from sqlalchemy import and_
words = ['%三%', '%猫%']
rule = and_(*[table.u_name.like(w) for w in words])
table.query.filter(rule)
DBSession().query(user).filter(user.u_name.like('%三%')).filter(user.u_name.like('%猫%'))
# 或者 and_()
DBSession().query(user).filter(and_(user.u_name.like('%三%'), user.u_name.like('%猫%')))